T4 polynucleotide kinase and RNA repair

Structure and mechanism of T4 polynucleotide kinase: an RNA repair enzyme -- Wang et al. 21 (14): 3873 -- The EMBO Journal: "The use of bacteriophage T4 Pnk to label 5' DNA or RNA ends with 32P was instrumental in the development of methods for the analysis of nucleic acid structure, molecular cloning and nucleic acid sequencing. Although the historical importance of T4 Pnk in the recombinant DNA revolution is well known, it is less widely appreciated that T4 Pnk spearheads a pathway of �RNA repair� in vivo. During T4 infection, Pnk participates in an elaborate pathogen�host dynamic whereby the bacterium attempts to thwart T4 protein synthesis by inducing site-specific breakage of host-cell tRNAs, to which the phage responds by repairing the broken tRNAs using Pnk and a phage-encoded RNA ligase "