oncogene aa tumor suppressor

Genome Biology | Full text | DNA-damage signaling and apoptosis: "Unlike c-Abl which continuously shuttles between the nucleus and the cytoplasm, oncogenic forms of Abl, such as Bcr-Abl, are exclusively cytoplasmic. If Bcr-Abl is trapped in the nucleus, it activates apoptosis. Essentially, an oncogene has thereby been converted into a tumor suppressor. Furthermore, this observation establishes the principle that the decision to undergo apoptosis can be regulated by the subcellular localization of c-Abl."