BER glycosylases

MOLECULAR BIOLOGY: ON DNA-REPAIR ENZYMES: Base excision repair (BER) is a specialized pathway that plays a primary role in repairing damaged DNA bases. The damaged base is first removed by specific BER glycosylases, followed by excision of the remaining sugar fragment, and finally, installation of an undamaged nucleotide by a DNA polymerase. Of note, inherited defects in BER have recently been linked to colorectal cancer.