ATM Signaling and DNA Damage

ATM Signaling and DNA Damage: "The ATM protein kinase, the caretaker of the genome, plays an important role in this process of maintaining genomic integrity. In response to DNA damage, ATM and other checkpoint proteins initiate a complex signal transduction cascade to halt the cell cycle and facilitate repair.
This can involve different types of cellular machinery, depending on the nature of the lesion. Many of the phosphorylation events that are catalyzed by ATM are critical to the cell cycle arrest and the subsequent repair process."