2005/11/24

Scientists Discover How Protein Crucial For Motion Is Synthesized At The Right Place In The Cell

Scientists Discover How Protein Crucial For Motion Is Synthesized At The Right Place In The Cell: "'The ZBP1 bound to actin's messenger RNA acts like a lock to prevent it from being translated into protein before reaching its destination,' explains Dr. Singer. 'On arriving at the cell periphery, the messenger RNA/ZBP1 complex encounters an enzyme, the protein kinase Src, which is active only in that part of the cell. Src adds a phosphate group to ZBP1 close to where it binds to messenger RNA, and this phosphorylation reaction detaches ZBP1 from the actin messenger RNA--unlocking the messenger RNA so it can now be translated into the actin protein that makes cell movement possible.'"

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