p53 Clumps and Pediatric Adrenocortical Cancer

Collapse Of p53 Into Clumps Might Be Linked To Cancer, According To St. Jude: "The mutation that causes clumps to form is associated only with the pediatric cancer adrenocortical carcinoma (cancer of the outer layer of the adrenal gland), suggesting a link between clump formation for mutant p53 in adrenal cells and the resulting cancer. Although the current finding only suggests a link between p53 clumps and adrenocortical carcinoma, mutations that disrupt various proteins have broader implications. The resulting aggregates, called amyloid fibrils, are also associated with diseases such as Alzheimer's and Parkinson's."